In vitro permeation of a pegylated naltrexone prodrug across microneedle-treated skin
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چکیده
منابع مشابه
Enhanced skin permeation of naltrexone by pulsed electromagnetic fields in human skin in vitro.
The aim of the present study was to evaluate the skin permeation of naltrexone (NTX) under the influence of a pulsed electromagnetic field (PEMF). The permeation of NTX across human epidermis and a silicone membrane in vitro was monitored during and after application of the PEMF and compared to passive application. Enhancement ratios of NTX human epidermis permeation by PEMF over passive diffus...
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The use of a prodrug, a conjugate of an active drug with a lipophilic substituent, is a good way of increasing the cutaneous absorption of a drug. However, the activity of dermal hydrolases has rarely been investigated in humans, or experimental animals. In the present study, we focused on the identification of rat dermal esterases and the hydrolysis of a prodrug during permeation across rat sk...
متن کاملPermeation of antigen protein-conjugated nanoparticles and live bacteria through microneedle-treated mouse skin
BACKGROUND The present study was designed to evaluate the extent to which pretreatment with microneedles can enhance skin permeation of nanoparticles in vitro and in vivo. Permeation of live bacteria, which are physically nanoparticles or microparticles, through mouse skin pretreated with microneedles was also studied to evaluate the potential risk of microbial infection. METHODS AND RESULTS ...
متن کاملIn vitro percutaneous permeation of the repellent DEET and the sunscreen oxybenzone across human skin.
PURPOSE DEET and oxybenzone are two essential active ingredients in repellent and sunscreen products. The percutaneous permeation of the two compounds across human skin from five commercially available repellent and sunscreen products was investigated in vitro. METHODS Diffusion studies were carried out at 37 degrees C, using Franz-style diffusion cells and human epidermis (380 microm in thic...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2010
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2010.05.034